In our review, we had been ready to appreciably escalate the dose of CX-5461 beyond that realized in the primary-in-human study in clients with hematologic cancers. The RP2D of 475?mg/m2 on days one, eight, and fifteen of the 4-7 days cycle, was based on phototoxicity, which happened despite rigid UV light-weight avoidance protocols and in the abse